Abstract: Neurotrophic keratitis is a kind of refractory corneal disease. Trigeminal nerve injury due to various reasons could lead to changes in nerve morphology, decreased secretion function and sensitivity, which would trigger corneal inflammatory response, causes epithelial defects, delayed healing, corneal ulcers and a series of pathological changes. At present, the new treatment strategy is mainly the use of nerve growth factor (NGF). Although nerve transplantation is proved to be effective by clinical practice, the difficulty of surgery and the risk of trauma make it need further clinical study. Pergolide and nanomicelle curcumin are expected to provide new therapeutic ideas for clinical use.(Int Rev Ophthalmol, 2021, 45: 326-330)